Z tego co zrozumiałm bo nie zrozumiałm do konca
Chodzi o to ze minocyklina moze wpływac na neurotransmiter GABA i
dlatego wystepują po minocyklinie zawroty glowy, nudnosci a czasami
oczoplas nie ma to nic wspolnego z herxem.
Do produkcji GABA niezbedna jest wit B6. Zrobiono takie badanie ze
były 2 grupy osob- jednej podawno 700mg mino przez 3 dni a drugiej
grupie osob tak samo tylko ze z witamina B6 dakwa 7x 40mg (280mg) .
Tylko uwaga bo w tej pracy przynajmniejw streszeniu nie ma info czy
to mino 700mg i 280mg B6 była to dawka dzienna czy rozbita na 3 dni
( na zdrowy rozsadek to raczej na 3 dni)
W tej grupie co brala samo mino te wszystkie skutki uboczne
wystapily w drugiej grupie tej z wit b6 byly znacznie mniejsze.
to tyle jak chodzi o stresczenie, ciekawe jest to ze nawet u osob u
ktorych wystepowały te wszystkie skutki uboczne przechodza one po
jakims czasie.
www.google.pl/search?sourceid=navclient&ie=UTF-8&rlz=1T4ADBF_enPL246PL246&q=Antivertiginous+action+of+vitamin+B+6+on
+experimental+minocycline-induced+vertigo+in+man
By means of a former investigation it has been proved
equilibriometrically that the application of 7 X 100 mg minocycline
may induce a central equilibrium dysregulation of the brainstem
type. It was the purpose of this study to further assure that the
minocycline induced brainstem vertigo is due to a destabilization of
a supervisory gamma-aminobutyric acid (GABA)ergic loop from the
archeocerebellum upon the pontomedullary vestibular regulating
pathways. As it is pharmacologically known that pyridoxine is
essential for the synthesis of GABA, an inhibitory CNS
neurotransmitter, 2 separate double blind trials on 20 healthy young
persons each were carried out after the intake of 7 X 100 mg
minocycline during 3 days with and without 7 X 40 mg pyridoxine
simultaneously.
These trials were checked against an additional placebo or initial
non drug investigation. In all the 40 test persons it could be
proved that the amount of vertigo and nausea symptoms was increased
significantly due to the application of minocycline only. However,
when combining minocycline with vitamin B 6, the vertigo and nausea
symptoms as well as the nystagmus signs from the monaural and the
binaural vestibular ocular tests as well as the vestibular spinal
signs from the craniocorpography recordings of the stepping and the
standing procedures were remarkably reduced.
There were no statistical differences between the initial or placebo
trials versus the trials with a combination of minocycline with
vitamin B 6. The same holds for the vestibular vegetative reactions,
measured by the simultaneous electrocardiography during the
vestibular tests. All the equilibriometric tests applied showed a
significant destabilization under the influence of a pure
minocycline loading
pozdr
zaz
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