Gość: :(
IP: *.tychy.msk.pl
05.10.04, 14:58
Wystarczy mi tak mniej wiecej wytłumaczenie tego co tu pisze. Z góry bardzo
dziekuje.
Background: Idiopathic guttate hypomelanosis (IGH) is an acquired, benign
leukoderma of unknown etiology. It is most commonly a complaint of middle-
aged,
light-skinned women, but it is increasingly seen in both sexes and older dark-
skinned people with a history of long-term sun exposure.
IGH is a benign condition. The cause is not known, but it appears to be
related
to the effect of the sun on melanocytes, which makes them effete.
A variety of therapeutic methods, including topical steroids, topical
retinoids, dermabrasion, cryotherapy, and minigrafting, have been used with
variable success.
Pathophysiology: Because pigmentation of the skin is due to an integration of
melanocyte and keratinocyte function, an acquired defect of the epidermal
melanin unit results in the observed hypopigmentation.
Significantly fewer dopa oxidase-positive, KIT+, and melanocytes are seen in
the lesions.
In 1967, Hamada and Saito found a 50% reduction in melanocytes.
Frequency:
In the US: IGH is a very common condition to the point of being almost
universal in elderly fair-skinned individuals.
Internationally: This disease is most common in countries with fair-skinned
populations having a high degree of sun exposure.
Mortality/Morbidity: This condition is cosmetic alone, albeit, it is
indicative
of cumulative sun exposure.
Race: IGH affects fair-skinned people at an earlier age.
Sex:
This condition is seen far more frequently in women, beginning around the age
of 30 years. However, with increasing age and sun exposure, it is found
almost
equally in elderly men and women.
Why IGH occurs earlier in young women than in young men is unknown.
Age:
This condition is related to the lack of pigmentary protection from the sun
and
sun exposure rather than to age.
Fair-skinned women develop this condition first; later, with increasing age
and
exposure to sun, both sexes seem to be equally affected.