Oferta pracy - Firma Advanced Cancer Therapeutic

[malossep]

FINANCING PROGRAMME: QUICK PATH 1.1.1 NCBR
PROJECT TITLE: Targeting the RSV Receptor Nucleolin: a Novel Approach to RSV Therapy and prophylaxis
GOAL: To develop the newly RSV treatment strategy based on the GRO-777 drug capable to inhibit the cell surface receptor of RSV and a novel drug delivery system

We are looking for people to our project (Conditional work agreement - Warunkowa Umowa o Pracy)
Please contact us: [e-mail]

Job description
Position: Molecular / Cell Biologist Research Associates
Reports To: R&D Director

Position Overview
The Molecular/ Cell biologist will work under the leadership of the R&D Director. He/She will design, perform, and analyze experiments, follow and incorporate relevant published findings related to research, methodologies and technologies, keep accurate and up-to-date records, communicate results in group presentations and propose scientifically based recommendations. This will require including biochemical, molecular and functional assays to characterize the novel therapeutic products of the company based on small molecules and DNA-based oligonucleotides in a variety of cell-based systems in the fields of infectious disease, immunology, and oncology to support the optimization of novel compounds, selection of clinical candidates, and CDT/IND submissions.

Responsibilities:
• Perform day to day experimental activities to characterize and screen novel therapeutic compounds (small molecules and DNA-oligonucleotides), their mechanisms of action, their potential use as preclinical and clinical compounds
• Perform standard and novel molecular, cellular, and functional assays
• Maintain expertise in the areas of microbiology, immunology or molecular biology as related to infectious diseases, immunology, oncology
• Perform basic molecular biology techniques, antigen/antibody purification, experience with monoclonal antibodies, spectroscopic and microscopic methodologies, bacterial and cell culture, DNA/RNA purification, cloning, PCR, etc.
• Experience should include the development of functional cell-based assays that quantitatively measure changes in cellular signaling activity, proliferation, cell viability, and/or receptor internalization.

Requirements:
• BS/MS degree in Biology or a related field with and 7+ (BS) or 4+(MS) years relevant experience
• 5+ years industry experience in cell biology, oncology or immunology.
• Experience should include the development of functional cell-based assays that quantitatively measure changes in cellular signaling activity, proliferation, infection, cell viability, and/or receptor internalization, including multi-color flow cytometry (FACS)
• Experience with isolation and culture of primary immune cells, as well as a comprehensive knowledge of the basics of cellular immunology as it applies to infectious diseases and cancer is preferred
• Common biochemistry and molecular biology techniques, including Western blotting, ELISA, qPCR, DNA/RNA, cell separation, and transfection.
• Excellent written, oral, communication, versed in English (written and spoken)
• Work well with others and excellent organizational skills.

Position: Analytical Chemist, Research Associate
Reports To: Analytical Manager

Position Overview
The Analytical Chemists will work under the leadership of the Analytical Services Manager to support the analytical needs of the different Departments of the company. They will be responsible for installation and maintenance of the analytical equipment as well as for developing methods, collecting the data to support validation and transfer of multiple and diverse methods and preparing related documentation and reports.


Responsibilities:
• Install and maintain analytical equipment (IR/UV analysis, Assays GC/HPLC analysis, LC-MS analysis, KF, Polarimetry, )
• Perform measurements, computations, tabulation, and analyze results related to the testing conducted.
• Perform non-routine instrumental analysis and wet chemistry analysis
• Operate and maintain/calibrate laboratory equipment
• Maintain laboratory records
• Perform analysis and lab related duties as per GLP/ cGMP
• Write technical and method reports and undertake deviations, OOS, OOT, and change controls
•

Requirements:
• B.S. and 8+ years or M.S. and 6+ years of experience in pharmaceutical or biotechnology industry
• Expertise in method development, qualification, and validation
• Familiar with regulatory documentation (protocols, study reports, deviations, OOS, OOT, and change controls) and regulatory guidelines
• Experience developing and validating analytical methods and analyzing and interpreting data (ideally HPLC/MS, NMR, DLS, KF, GPC, and DSC and molecular biology techniques)
• Experience with installing and maintaining analytical equipment
• Perform measurements, computations, tabulation, and analyze results related to the testing
• Excellent written, oral, communication, versed in English (written and spoken)
• Work well with others and excellent organizational skills.

Job description
Position: Formulation Scientist
Reports To: R&D Director

Position Overview
The Formulation Scientist will be responsible for planning and performing laboratory experiments to develop new product formulations (parenteral, inhalation…) to support the R&D, preclinical and clinical activities and goals. Working in collaboration with the preclinical and clinical Departments, he will provide formulations that satisfy the desired product specifications and utility. He will need to use multiple and diverse analytical methods o support his efforts.

Responsibilities:
• Independently develop experimental designs and work plans in the development of new products / formulations to meet desired product performances.
• Leads projects in collaboration with other departments and translating their needs into technical specifications.
• Investigate the stability of new formulations
• Responsible for planning, interpretation, quality and presentation of data. Reports progress/issues on a timely basis. Establish potential product specifications
• Interact with CMOs to transfer manufacturing and processes
• Responsible for following all applicable FDA and EMEA regulations and safety and toxicity guidance

Experience Required:
• M.S. and 8+ years or Ph.D. and 4+ years of experience in the formulation of new product
• Parenteral, oral and inhalation experience preferred
• Thorough knowledge of GMPs, ICH, USP, EP regulations and in regulatory documentation (protocols, study reports, deviations, OOS, OOT, and change controls)
• Understanding of appropriate analytical techniques and specifications required for DP
• Excellent written, oral, communication, well versed in English (written and spoken), leadership and organizational skills
• Results oriented and self-motivated
Pascal Malosse