tosho
21.01.08, 17:53
Tu jest zarchiwizowany watek na temat tego antybiotyku:
forum.gazeta.pl/forum/72,2.html?f=26140&w=26238096&a=45440524
Ketek jest dostepny w Niemczech.
Wg Burrascano:
Jest to najlepszy makrolid (ketolid) na Bb, a byc moze nawet najlepszy doustny
antybiotyk na Bb.
Można spodziewać się dużych reakcji herxheimera.
W odroznieniu od pozostalych makrolidów nie wymaga amantadyny ani
hydroxychlorochiny.
Jest dosyc ciężki na wątrobę.
Niestety nieefektywny na bartonellę.
Burrascano o Ketek-u (z jego wytycznych) :
Telithromycin, on the other hand, is stable in the intracellular acid
environment, which may be why this is
currently by far the most effective drug of this class, and may replace the
others in the majority of patients
with LB. Likewise, there is no need to co-administer amantadine or
hydroxychloroquine. This antibiotic has
other advantages- it has been engineered to prevent drug resistance, has
almost no negative impact on E.
coli in the intestinal tract (hopefully minimizing the risk for diarrhea), and
it can be taken with or without food.
However, there are disadvantages:
1. May interact with a wide variety of medications because it is an inhibitor
of the cytochrome
CYP3A4. It is vital that this be taken into account as many Lyme patients take
a variety of
medications concurrently, and often from several practitioners.
2. May lengthen the QT interval. This should be measured prior to prescribing
this drug, and if
borderline, rechecked after it is begun.
3. Can transiently cause blurry vision, delayed accommodation, and even double
vision.
4. Liver enzymes may become elevated. Blood tests should be done regularly to
monitor this.
5. The usual precautions of any antibiotic also still apply- risk for allergy,
stomach upset,
Herxheimer reactions, etc.
Telithromycin- Adolescents and adults: 800 mg once daily
Do not need to use amantadine or hydroxychloroquine
So far, the most effective drug of this class, and possibly the best oral agent
if tolerated. Expect strong and quite prolonged Herxheimer reactions.
Must watch for drug interactions (CYP3A-4 inhibitor), check the QTc interval, and
monitor liver enzymes.
Not to be used in pregnancy.
Z konferencji Hope to Heal Lyme 2006. Burrascano na temat makrolidów na Bb:
www.betterhealthguy.com/images/stories/pdf/HopeToHealLyme2006.pdf
Zithromax is only intracellular. However, it is not a good drug for Lyme.
Biaxin is a much better drug. Ketek is by far the best. May be 10x better than
IV Rocephin but it is hard on the liver and the heart. People usually have a
difficult time and may herx for 1-2 months. It is killing germs that have
never been killed before.
Tu jest cos dziwnego napisane: ze niby ketek jest 10 razy lepszy od
ceftriaksonu??? (biotraksonu)
