franiolek1
10.06.08, 09:54
Primaquine is the only available drug to treat Plasmodium vivax
liver stages (hypnozoites) . It has been used for more than five
decades and is now included in an increasing number of clinical
guidelines. The major concern is induced hemolysis when administered
to glucose-6-phosphate -dehydrogenase deficient patients. Primaquine
could be used for causal prophylaxis during and after exposure or
for presumptive antirelapse therapy (PART) in case of high exposure
to P. vivax. A radical cure is used to avoid relapse for patients
with a confirmed bloodstream infection with P. vivax or P. ovale. In
France, primaquine is not approved for prevention and treatment and
its use requires a specific temporary authorization.