Gość: Marsylka28
IP: *.ppp.tiscali.fr
31.08.04, 20:18
Czy przyjmowanie Propecii przez mezczyzne przez czas dluzszy niz 2 lata moze
miec wplyw na jakosc spermy ? Moj maz ma 28 lat i fatalne wyniki spermogramu;
chcialabym wiedziec czy finasterydy moga miec z tym jakis zwiazek..
Serdecznie dziekuje za porade.
A taki artykul znalazlam w internecie :
Carcinogenesis, Mutagenesis, Impairment of Fertility - Propecia
These concentrations correspond to 18,000-22,000 times the peak plasma levels
in man given a total dose of 1 mg. No evidence of mutagenicity was observed
in an in vitro bacterial mutagenesis assay, a mammalian cell mutagenesis
assay, or in an in vitro alkaline elution assay. In an in vitro chromosome
aberration assay, when Chinese hamster ovary cells were treated with high
concentrations (450-550 µmol) of finasteride, there was a slight increase in
chromosome aberrations. Further, the concentrations (450-550 µmol) used in in
vitro studies are not achievable in a biological system. In an in vivo
chromosome aberration assay in mice, no treatment-related increase in
chromosome aberration was observed with finasteride at the maximum tolerated
dose of 250 mg/kg/day (1,824 times the human exposure, estimated) as
determined in the carcinogenicity studies.
In mice at a dose of 25 mg/kg/day (184 times the human exposure, estimated)
and in rats at a dose of ≥40 mg/kg/day (312 times the human exposure) an
increase in the incidence of Leydig cell hyperplasia was observed. A positive
correlation between the proliferative changes in the Leydig cells and an
increase in serum LH levels (2-3 fold above control) has been demonstrated in
both rodent species treated with high doses of finasteride. In a 19-month
carcinogenicity study in CD-1 mice, a statistically significant (p≤0.05)
increase in the incidence of testicular Leydig cell adenomas was observed at
a dose of 250 mg/kg/day (1,824 times the human exposure). No drug-related
Leydig cell changes were seen in either rats or dogs treated with finasteride
for 1 year at doses of 20 mg/kg/day and 45 mg/kg/day (240 and 2,800 times,
respectively, the human exposure) or in mice treated for 19 months at a dose
of 2.5 mg/kg/day (18.4 times the human exposure).
This decrease in fertility in finasteride-treated rats is secondary to its
effect on accessory sex organs (prostate and seminal vesicles) resulting in
failure to form a seminal plug. All these effects were reversible within 6
weeks of discontinuation of treatment. No drug-related effect on testes or on
mating performance has been seen in rats or rabbits. In sexually mature male
rabbits treated with finasteride at 80 mg/kg/day (4,344 times the estimated
human exposure) for up to 12 weeks, no effect on fertility, sperm count, or
ejaculate volume was seen. In sexually mature male rats treated with 80
mg/kg/day of finasteride (488 times the estimated human exposure), there were
no significant effects on fertility after 6 or 12 weeks of treatment;
however, when treatment was continued for up to 24 or 30 weeks, there was an
apparent decrease in fertility, fecundity, and an associated significant
decrease in the weights of the seminal vesicles and prostate. The seminal
plug is essential for normal fertility in rats but is not relevant in man.
These doses produced respective systemic exposure in rats of 888 and 2,192
times those observed in man receiving the recommended human dose of 1 mg/day.
No evidence of a tumorigenic effect was observed in a 24-month study in
Sprague-Dawley rats receiving doses of finasteride up to 160 mg/kg/day in
males and 320 mg/kg/day in females. All exposure calculations were based on
calculated AUC(0-24 hr) for animals and mean AUC(0-24 hr) for man (0.05
µg•hr/mL). Top
