Jad pszczół (mellityna) wykazuje bardzo silne działanie przeciw Bb, w
badaniach in vitro.
1: Clin Infect Dis 1997 Jul;25 Suppl 1

48-51Related Articles, Books
The antimicrobial agent melittin exhibits powerful in vitro inhibitory effects
on the Lyme disease spirochete.
Lubke LL, Garon CF
Rocky Mountain Laboratories Microscopy Branch, National Institute of Allergy
and Infectious Diseases, National Institutes of Health, Hamilton, Montana
59840, USA.
Borrelia burgdorferi has demonstrated a capacity to resist the in vitro
effects of powerful eukaryotic and prokaryotic metabolic inhibitors.
However, treatment of laboratory cultures on Barbour-Stoenner-Kelly medium
with melittin, a 26-amino acid peptide contained in honeybee venom, showed
immediate and profound inhibitory effects when they were monitored by
dark-field microscopy, field emission scanning electron microscopy, and
optical density measurements.
Furthermore, at melittin concentrations as low as 100 microg/mL, virtually all
spirochete motility ceased within seconds of inhibitor addition.
Ultrastructural examination of these spirochetes by scanning electron
microscopy revealed obvious alterations in the surface envelope of the
spirochetes.
The extraordinary sensitivity of B. burgdorferi to mellitin may provide both a
research reagent useful in the study of selective permeability in
microorganisms and important clues to the development of effective new drugs
against lyme disease.
PMID: 9233664, UI: 97376893