jan-w
24.05.08, 11:53
Czytał ktoś może o tym leku nowej generacji przeciw chronicznemu HCV, HBV i
HIV? Nie jest to kolejna wersja mieszanki interferonowej. Informacje jakie
znajduję są straszliwie specjalistyczne.
Najbardziej "zrozumiały" abstract jaki znalazłem:
Successful elimination of the hepatitis C virus (HCV) during acute infection
has been linked to strong HCV-specific in vitro T-cell proliferation, whereas
T cells from patients with chronic hepatitis C respond only weakly to HCV
antigens. Lipid-coupled peptides are immunostimulants, which might provide a
basis for novel therapeutic strategies against HCV. Therefore, in 20 patients
with chronic hepatitis C, we studied whether tri-palmitoyl-S-cysteine-coupled
peptides could modify in vitro T-cell proliferation (by [3H]thymidine uptake)
in response to virus core and NS4. The lipopeptides corresponded to five
immunodominant T helper epitopes of HCV core. Contrary to unmodified peptides,
the lipopeptides specifically enhanced [3H]thymidine uptake in response to HCV
antigens but not to a non-HCV related control antigen. They increased the
frequency of responders (stimulation index, SI ≥ 4) to core (13/20 versus
2/20; p = 0·0008) and NS4 (20/20 versus 7/20; p < 0·0001) among our patients
with chronic hepatitis C. This immunostimulatory effect was dose-dependent,
and was observed specifically with lipopeptides corresponding to the HCV
epitopes. Our data demonstrate that the poor in vitro T-cell proliferation of
patients with chronic hepatitis C can be improved when T cells are
co-stimulated with HCV core-derived T helper lipopeptides, while the same
peptides in unlipidated form had no effects. Thus, lipopeptides corresponding
to HCV T-cell epitopes may offer novel immunomodulatory strategies against HCV.
