Bio Bran,Betulina a Selol

16.12.07, 16:54
Zapoznałem sie z dostępnymi w Goglach materiałami dot.trzech w/wym.preparatów
i doszedłem do wniosku,ze ktoś albo wszyscy ich autorzy zwyczajnie "zżynają
"opisując ich działanie na komórki rakowe wywołujące apoptozę.
Mam pytanie,czy z innymi preparatami jak Selol Państwo się zetknęliście i co o
nich sadzicie.Czytałem dużo wywodów scepta89 i emgoro wiec ich opinie na pewno
wiele by wniosły.Dla ułatwienia przesyłam;
www.sylveco.pl/index.php?file=4&lan=p
    • scept89 betulina / kwas betulinowy 21.12.07, 14:47
      Zzarlo mi komentarz tak ze b. skrotowo (ang):

      stosowanie i ew. przeciwwskazania (niepelne!):
      www.cancer.org/docroot/ETO/content/ETO_5_3x_White_Birch.asp?sitearea=ETO
      wlasciwosci:
      Pharmacological properties of the ubiquitous natural product betulin
      Alakurtti et al
      European Journal of Pharmaceutical Sciences
      Volume 29, Issue 1, September 2006, Pages 1-13

      Abstract
      """
      Betulin (lup-20(29)-ene-3β,28-diol) is an abundant naturally occurring
      triterpene and it is found predominantly in bushes and trees forming the
      principal extractive (up to 30% of dry weight) of the bark of birch trees.
      Presently, there is no significant use for this easily isolable compound, which
      makes it a potentially important raw material for polymers and a precursor of
      biologically active compounds. Betulin can be easily converted to betulinic
      acid, which possesses a wide spectrum of biological and pharmacological
      activities. Betulinic acid has antimalarial and anti-inflammatory activities.
      Betulinic acid and its derivatives have especially shown anti-HIV activity and
      cytotoxicity against a variety of tumor cell lines comparable to some clinically
      used drugs. A new mechanism of action has been confirmed for some of the most
      promising anti-HIV derivatives, which makes them potentially useful additives to
      the current anti-HIV therapy. Betulinic acid is specifically cytotoxic to
      several tumor cell lines by inducing apoptosis in cells. Moreover, it is
      non-toxic up to 500 mg/kg body weight in mice. The literature concerning
      derivatization of betulin for structure–activity relationship (SAR) studies and
      its pharmacological properties is reviewed.
      """

      Dzialanie:
      Betulinic acid inhibits prostate cancer growth through inhibition of specificity
      protein transcription factors.
      Chintharlapalli et al
      Cancer Res. 2007 Mar 15;67(6):2816-23.
      cancerres.aacrjournals.org/cgi/content/full/67/6/2816
      Pozdr
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