Ki-67<1% - co to oznacza?

[madzia.a]

Wiem, że jest to antygen rakotwórczy. Co można powiedzieć o tym antygenie w przypadku raka kości?

[osmanthus]

Madzia.a,
nie zakladaj nowych watkow, pisz w jednym, w przeciwnym razie
wszyscy sie w nich pogubimy.
Ki-67 nie jest antygenem rakotworczym (powodujacym raka). Jest to
antygen wystepujacy w proliferujacych komorkach.
Poziom ekspresji Ki-67 wskazuje na agresywnosc guza.

W moim poprzednim poscie pytalam dokad wyslano pobrany material.
Teraz mysle, ze byc moze do Bolonii.


Clinical relevance of Ki-67 expression in bone tumors
Katia Scotlandi, M.S., Massimo Serra, M.S., M. Cristina Manara,
M.D., Daniela Maurici, M.S., Stefania Benini, M.S., Giuseppe Nini,
M.S., Mario Campanacci, M.D., Nicola Baldini, M.D. *
Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli,
Bologna, Italy
*Correspondence to Nicola Baldini, Laboratorio di Ricerca
Oncologica, Istituti Ortopedici Rizzoli, Via di Barbiano, 1/10,
40136 Bologna, Italy

Funded by:
Associazione Italiana per la Ricerca sul Cancro
Istituti Ortopedici Rizzoli, Ricerca Corrente 9489

KEYWORDS
Ki-67  bone tumors  grading  immunofluorescence
ABSTRACT
Background. The availability of Ki-67 monoclonal antibody has opened
new possibilities for an extensive analysis of cell kinetics in
human neoplasms. Ki-67 antibody reveals a nuclear antigen that is
expressed in proliferating but not in quiescent cells. Although the
reliability of Ki-67 immunostaining has been evaluated in different
tumor types, little information has been reported on bone neoplasms.
Methods. Cell proliferation, as determined by Ki-67 expression, was
measured by immunofluorescence on representative cytospins obtained
from 205 patients with bone tumors. In each sample, the percentage
of Ki-67-positive cells was quantified on at least 500 cells and
expressed as Ki-67 labeling index (LI).
Results. Ki-67 LI was lower in benign and low grade lesions as
compared with high grade malignant lesions. A correlation between
Ki-67 LI and histologic grade was observed in osteosarcoma and
chondrosarcoma. In osteosarcoma, among the 43 primary lesions
included in this study, 30 patients, all treated with the same
regimen of chemotherapy and limb-salvage surgery, were selected to
establish the prognostic significance of cell proliferation. The Ki-
67 labeling was higher in patients with a good histologic response
to chemotherapy. However, at a 24-month follow-up, a worse prognosis
was associated with a higher proliferative activity, whereas no
correspondence was found between the histologic response to
preoperative chemotherapy and the disease free survival, suggesting
that in high grade osteosarcoma the biologic aggressiveness
expressed by high levels of Ki-67 LI may be clinically more relevant
than the responsiveness to antineoplastic agents.
Conclusions. In bone tumors, the level of Ki-67 expression
correlates with the level of malignancy and is diagnostically and
prognostically useful. Cancer 1995;75:806-14.
Received: 20 September 1994; Accepted: 14 October 1994